Wellbutrin SR and XL are both used to treat depression, but they have other FDA-approved uses that are different. They’re also taken differently. Find patient medical information for Bupropion (Wellbutrin, Zyban, and others) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Use in Smoking Cessation Treatment: WELLBUTRIN®, WELLBUTRIN SR®, and WELLBUTRIN XL are not approved for smoking cessation treatment, but bupropion under the name ZYBAN® is approved for this use. Serious neuropsychiatric events, including but not limited to depression, suicidal ideation, suicide attempt, and completed suicide have been reported in patients taking bupropion for smoking. Bupropion is sold under different brand names. If you are already taking medicine for depression or to help you stop smoking, discuss this with your doctor before taking bupropion. It is very important that you receive only one prescription at a time for bupropion. This medicine is available only with your doctor's prescription. Bupropion, formerly called amfebutamone, [17] and sold under the brand name Wellbutrin among others, is an atypical antidepressant that is indicated in the treatment of major depressive disorder and seasonal affective disorder and to support smoking cessation. [18][19] It is a norepinephrine–dopamine reuptake inhibitor (NDRI). Some evidence-based guidelines support first-line use. [20] It is. Wellbutrin (bupropion) is used to treat major depressive disorder and seasonal affective disorder. Includes Wellbutrin side effects, interactions and indications. This guide is adapted from the clinician guide authored by Sebastián Malleza, M.D., M.Sc. at the Psychopharmacology Institute. For the complete clinical resource, visit: Bupropion Guide: Pharmacology, Indications, Dosing Guidelines and Adverse Effects What is Bupropion? Bupropion (brand names include Wellbutrin, Wellbutrin SR, Wellbutrin XL, and others) is a medication used to treat major. Wellbutrin is a prescription drug used for depression and seasonal affective disorder (SAD). Learn about the drug’s dosages, forms, strengths, and more. Wellbutrin is prescribed to treat major depressive disorder and prevent seasonal affective disorder. Learn about the drug’s dosages and more. Wellbutrin XL (Bupropion Hydrochloride Extended-Release) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources.